Michèle Drouin began her studies at the École des Beaux-Arts in Québec in 1951. She received her Master of Fine Arts at Concordia University in 1973.
Drouin painted and studied ceramics. Influenced by the figurative style of Jean-Paul Lemieux.
In the early 1960's Drouin began writing and became famous for her poems on the radio and in the press.
During the 1970s, her paintings were influenced by Robert Delaunay and contemporary American abstract painting.
In 1983 she was invited to attend the workshop Triangle Artist's Studio in New York. In 1997 she was the artist in residence at The International Cultural Centre of Hammamet in Tunisia. In 1992, she was appointed to the Royal Canadian Academy of Arts.
She has had several solo and group shows at institutions such as the Moore Gallery in Toronto, the Agnes Bugera Gallery in Edmonton, Galerie Orange in Montréal and Galerie Lacerte art contemporary Québec. Her work is part of the collections of the Museum of Contemporary Art in Montreal, Musée national des beaux-arts du Québec, National Museums Collection in Tunisia, and The National Library of Canada in Ottawa.