Clare Bice was born in 1909 in Durham, Ontario and raised in London, Ontario.
He received a Bachelor of Arts degree in History and English from the University of Western Ontario in 1928. From 1930 to 1932, he studied at the Art Students League of New York and Grand Central School of Art in New York.
His works include landscape paintings, portraits, and figure painting. He was also was a curator, and children's book author and illustrator.
From 1940 to 1972, he was the curator of the Williams Memorial Art Gallery and Museum, now the Museum of London.
He was the author and illustrator of five children books: Jory's Cove (1941), Across Canada: Stories of Canadian Children (1949), The Great Island (1954), A Dog for Davie's Hill (1956), and Hurricane Treasure (1965). He also illustrated six books by Canadian writer Catherine Anthony Clark from 1892–1977.
He was a member of the Ontario Society of Artists and from 1967 to 1970, he was the president of the Royal Canadian Academy of Arts. In 1973, he was made a Member of the Order of Canada.
He died in 1976.