Charlotte Schreiber was born in 1834. She attended Mr. Cary's School of Art, in London, and unofficial classical training from J.R. Herbert.
Schreiber painted portraits, landscapes and genre scenes in oil and watercolour. She also illustrted six books during the 1870's in England and Toronto.
In 1875 with her husband she moved to Toronto, Ontario.
Schreiber was elected to the Ontario Society of Artists in 1876, was the first woman to teach at the newly formed Ontario College of Art in 1877. She was elected a charter member of the Royal Canadian Academy in 1880, and remained the only female member until 1933.
Schreiber exhibited her work at the annual exhibitions of the Ontarion Society of Artists and the Royal Canadian Academy, the Art Association of Montréal, the Canadian Women's Art Association, the Toronto Industrial Exhibitions, the Philadelphia Centennial Exhibitions, the Paris Salon, and the World Columbian Exhibition in Chicago .
In 1898, Schreiber returned to England where she lived in Paignton, Devon, continuing to paint and sell her work.
She died in 1922.